Sugi Predict

Sugi Predict / Compounds / SCHEMBL7398581

SCHEMBL7398581

SCHEMBL7398581

CC(C)C(NC(=O)C(Cc1ccccc1)CC(O[Si](C)(C)C(C)(C)C)C(Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NC(=N)N

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 4/20 0.48
▸ PSEN2 P49810 4/20 0.48
▸ APH1B Q8WW43 4/20 0.48
▸ NCSTN Q92542 4/20 0.48
▸ APH1A Q96BI3 4/20 0.48
▸ PSENEN Q9NZ42 4/20 0.48
▸ APP P05067 1/20 0.48
▸ KLK5 Q9Y337 1/20 0.44
▸ BACE1 P56817 4/20 0.43
▸ CTSD P07339 2/20 0.41
▸ REN P00797 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7395776 0.89 PSEN1 (0.49) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7395774 0.89 PSEN1 (0.49) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7395779 0.89 PSEN1 (0.49) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7395773 0.89 PSEN1 (0.49) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7398613 0.88 KLK5 (0.58) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7403391 0.86 PSEN1 (0.64) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7400852 0.86 PSEN1 (0.64) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7394560 0.86 PSEN1 (0.64) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6446803 0.82 KLK5 (0.47) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL7283432 0.82 KLK5 (0.47) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993009132-A1 HIV PROTEASE INHIBITORS CONTAINING GUANIDINE SMITHKLINE BEECHAM CORPORATION (US) 1993-05-13 — — WO disclosed