Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375418 | 0.89 | PREP (0.60) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL7836712 | 0.86 | PREP (0.64) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL9873735 | 0.86 | PREP (0.64) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL19258607 | 0.86 | PREP (0.63) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL6696041 | 0.85 | PREP (0.83) | PREPNPSR1ACE2CTRB1ALDH1A1 | |
| SCHEMBL4977449 | 0.85 | PREP (0.83) | PREPNPSR1ACE2CTRB1ALDH1A1 | |
| SCHEMBL7443395 | 0.85 | PREP (0.60) | PREPNPSR1ACE2CTRB1ALDH1A1 | |
| SCHEMBL8272821 | 0.85 | PREP (0.65) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL13532966 | 0.85 | PREP (0.65) | PREPNPSR1ACE2CTRB1KMT2A | |
| SCHEMBL16419544 | 0.84 | PREP (0.67) | PREPNPSR1ACE2CTRB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036903-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1997-10-09 | — | — | WO | disclosed |