Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 17/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396216 | 0.87 | HTR2C (0.37) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL7398516 | 0.87 | HTR4 (0.40) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL8323434 | 0.86 | HTR4 (0.57) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL7448294 | 0.85 | HTR2C (0.58) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL7396504 | 0.82 | SLC6A2 (0.41) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL8464871 | 0.79 | HTR4 (0.52) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL8324023 | 0.72 | HTR4 (0.45) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL7400600 | 0.71 | HTR2C (0.46) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL7401704 | 0.71 | HTR4 (0.53) | HTR4HTR2CHTR3AADRA2CADRA1A | |
| SCHEMBL8321696 | 0.71 | HTR4 (0.47) | HTR4HTR2CHTR3AADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5580885-A | FOR TREATMENT OF GASTROINTESTINAL, CARDIOVASCULAR OR NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-12-03 | — | — | US | disclosed |
| WO-1993005038-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-18 | — | — | WO | disclosed |