Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.65 |
| ▸ | HTR2C | P28335 | 4/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.65 |
| ▸ | HTR1D | P28221 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | HTR2B | P41595 | 3/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.65 |
| ▸ | HTR3A | P46098 | 3/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.64 |
| ▸ | HTR3B | O95264 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804321 | 0.83 | HTR4 (0.67) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL1041174 | 0.78 | HTR4 (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL2939430 | 0.78 | HTR4 (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL2938877 | 0.77 | HTR2C (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7391969 | 0.76 | HTR4 (0.78) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL14905735 | 0.74 | HTR4 (0.72) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7399774 | 0.74 | HTR4 (0.65) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7423609 | 0.73 | HTR4 (0.66) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7402077 | 0.72 | KDM4E (0.40) | LMNA | |
| SCHEMBL8805316 | 0.72 | HTR4 (0.59) | HTR4HTR2CADRA2CHTR1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681583-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-22 | — | — | EP | claimed |
| EP-0681583-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 1995-11-15 | — | — | EP | claimed |
| WO-1994017071-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-04 | — | — | WO | claimed |
| EP-0681583-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-22 | — | — | EP | disclosed |
| EP-0681583-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017071-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-04 | — | — | WO | disclosed |