SCHEMBL7399437

SCHEMBL7399437

OCC=Cc1ccc2ccccc2c1Br

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.51
POLB P06746 1/20 0.47
RAB9A P51151 3/20 0.37
SMPD2 O60906 2/20 0.37
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP2A6 P11509 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NCEH1 Q6PIU2 2/20 0.36
DHODH Q02127 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
TP53 P04637 1/20 0.35
MAPK1 P28482 1/20 0.35
CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3267323 0.83 MAOB (0.48) MAOBPOLBRAB9ASMPD2TSHR
SCHEMBL7990497 0.83 MAOB (0.48) MAOBPOLBRAB9ATSHRALDH1A1
SCHEMBL7990495 0.83 MAOB (0.48) MAOBPOLBRAB9ATSHRALDH1A1
SCHEMBL3267319 0.83 MAOB (0.48) MAOBPOLBRAB9ASMPD2TSHR
SCHEMBL15338325 0.78 SMPD2 (0.54) SMPD2ALDH1A1MAPTSMN1; SMN2HDAC8
SCHEMBL1683795 0.78 SMPD2 (0.54) SMPD2ALDH1A1MAPTSMN1; SMN2HDAC8
SCHEMBL1683792 0.78 SMPD2 (0.54) SMPD2ALDH1A1MAPTSMN1; SMN2HDAC8
SCHEMBL3267521 0.77 MAOB (0.51) MAOBPOLBRAB9ATSHRALDH1A1
SCHEMBL3267518 0.77 MAOB (0.51) MAOBPOLBRAB9ATSHRALDH1A1
SCHEMBL16308839 0.75 MAOB (0.50) MAOBPOLBRAB9AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288261-B1 DRUGS FOR INHIBITION OF ENZYMES ABBOTT LABORATORIES 2001-09-11 US disclosed
WO-2000037433-A1 INHIBITORS OF MATRIX METALLOPROTEINASES ABBOTT LABORATORIES (US) 2000-06-29 WO disclosed