SCHEMBL7990495

SCHEMBL7990495

ClC/C=C/c1ccc2ccccc2c1Br

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.48
POLB P06746 1/20 0.43
CYP2A6 P11509 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HSD17B10 Q99714 2/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
HPRT1 P00492 1/20 0.34
CYP3A4 P08684 1/20 0.34
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PAX8 Q06710 1/20 0.33
DHODH Q02127 1/20 0.33
NCEH1 Q6PIU2 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
HIF1A Q16665 1/20 0.32
CYP1B1 Q16678 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7990497 1.00 MAOB (0.48) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL3267323 0.83 MAOB (0.48) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL7399437 0.83 MAOB (0.51) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL3267319 0.83 MAOB (0.48) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL8175856 0.78 RXRA (0.49) ALDH1A1MAPTSMN1; SMN2CYP1B1
SCHEMBL7006267 0.78 RXRA (0.49) ALDH1A1MAPTSMN1; SMN2CYP1B1
SCHEMBL3267521 0.77 MAOB (0.51) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL3267518 0.77 MAOB (0.51) MAOBPOLBCYP2A6ALDH1A1HSD17B10
SCHEMBL16308839 0.75 MAOB (0.50) MAOBPOLBALDH1A1NPC1MAPT
SCHEMBL14151516 0.73 POLB (0.47) MAOBPOLBCYP2A6ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288261-B1 DRUGS FOR INHIBITION OF ENZYMES ABBOTT LABORATORIES 2001-09-11 US disclosed