Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | CPA1 | P15085 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.42 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.42 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.42 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.42 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17598384 | 0.92 | CACNA1B (0.51) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL24206296 | 0.92 | CACNA1B (0.51) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7369240 | 0.91 | MME (0.47) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7367928 | 0.91 | MME (0.46) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7409019 | 0.86 | MME (0.54) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7367334 | 0.85 | CACNA1B (0.54) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7369445 | 0.84 | MME (0.52) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7405764 | 0.83 | MME (0.52) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7375477 | 0.83 | MME (0.52) | CACNA1BMMEACECPA1ACE2 | |
| SCHEMBL7405818 | 0.82 | CACNA1B (0.49) | CACNA1BMMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |