Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 11/20 | 0.65 |
| ▸ | FLT4 | P35916 | 11/20 | 0.65 |
| ▸ | KDR | P35968 | 11/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10932141 | 0.83 | FLT1 (0.69) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL3693620 | 0.82 | FLT1 (0.67) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL6394067 | 0.81 | FLT1 (0.61) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL1382333 | 0.80 | CA1 (0.59) | FLT1FLT4KDRL3MBTL1CA1 | |
| SCHEMBL7264925 | 0.80 | FLT1 (0.65) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL7402304 | 0.80 | TSHR (0.67) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL10420808 | 0.79 | EGFR (0.68) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL209631 | 0.79 | CA2 (0.56) | EGFRERBB2CA1CA2MMP1 | |
| SCHEMBL10989349 | 0.78 | FLT1 (1.00) | FLT1FLT4KDRL3MBTL1EGFR | |
| SCHEMBL22622149 | 0.78 | FLT1 (0.58) | FLT1FLT4KDRL3MBTL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |
| US-5441960-A | 1-pyrimidinylacetamide human leukocyte elastate inhibitors | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0636141-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021210-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |