Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397225 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL7397597 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL30036930 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL7399135 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL7395029 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL7395820 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL7396726 | 1.00 | HTR3A (0.59) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL9492632 | 0.84 | HTR3A (0.51) | HTR3AKCNH2 | |
| SCHEMBL9511589 | 0.81 | HTR3A (0.58) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| SCHEMBL9509199 | 0.81 | HTR3A (0.58) | HTR3AKCNH2HTR2ASLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246942-A | Central nervous system, anti-emetic and gastric prokinetic activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-09-21 | — | — | US | disclosed |
| WO-1991004738-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |