Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398110 | 0.78 | PDE10A (0.63) | ADORA3ADORA1PDE10A | |
| SCHEMBL404853 | 0.76 | PDE10A (0.38) | PDE10A | |
| SCHEMBL22987491 | 0.75 | ADORA3 (0.52) | ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL22988034 | 0.74 | MAOB (0.52) | ADORA3ADORA2AADORA1MAOBSMN1; SMN2 | |
| SCHEMBL22987489 | 0.74 | ADORA3 (0.48) | ADORA3ADORA2AADORA1MAOB | |
| SCHEMBL7395649 | 0.73 | ADORA3 (0.39) | PARP1ADORA3ADORA2AADORA1ELANE | |
| SCHEMBL22988033 | 0.73 | ADORA3 (0.50) | ADORA3ADORA2AADORA1PDE10A | |
| SCHEMBL10287060 | 0.72 | PDE10A (0.42) | PDE10ACDK4CCND1 | |
| SCHEMBL406026 | 0.71 | PDE10A (0.41) | PDE10A | |
| SCHEMBL405733 | 0.69 | HAVCR2 (0.55) | ADORA3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575442-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVO NORDISK AS (DK) | 1995-12-27 | — | — | EP | disclosed |
| EP-0575442-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | NOVO NORDISK AS (DK) | 1993-12-29 | — | — | EP | disclosed |
| US-5260298-A | Psychopharmaceuticals | NOVO NORDISK A/S (DK) | 1993-11-09 | — | — | US | disclosed |
| WO-1992015591-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVO NORDISK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |