Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365935 | 0.89 | MAOA (0.47) | NPC1RAB9AMAPTSMN1; SMN2PARP1 | |
| SCHEMBL6094454 | 0.89 | KCNQ3 (0.42) | AXLNPC1RAB9AMAPTSCN8A | |
| SCHEMBL6094495 | 0.86 | FFAR1 (0.45) | AXLBRD4 | |
| SCHEMBL6092968 | 0.85 | KDR (0.51) | AXLBRD4KDR | |
| SCHEMBL6093279 | 0.84 | KDR (0.39) | AXLSCN8ASCN10ABRD4KDR | |
| SCHEMBL6095684 | 0.84 | FFAR1 (0.39) | AXLBRD4ALDH1A1KDR | |
| SCHEMBL6092101 | 0.84 | BRD4 (0.39) | AXLNPC1RAB9AMAPTSCN8A | |
| SCHEMBL6094231 | 0.83 | AXL (0.38) | AXLSCN8ASCN10ASMN1; SMN2BRD4 | |
| SCHEMBL4322760 | 0.83 | KDR (0.38) | AXLSCN8ASCN10ABRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6095387 | 0.83 | KDR (0.38) | AXLSCN8ASCN10ABRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725775-B1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 1998-07-22 | — | — | EP | claimed |
| WO-1998002420-A9 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | — | 1998-04-23 | — | — | WO | claimed |
| US-5925770-A | GAMMA-AMINOBUTYRIC ACID DERIVATIVES FOR DIAGNOSIS OR TREATMENT OF ANXIETY, SLEEP DISORDERS, SEIZURES, OVERDOSES OF BENZODIAZEPINE TYPE DRUGS, COGNITION ACTIVATORS | NEUROGEN CORPORATION (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0725775-B1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 1998-07-22 | — | — | EP | disclosed |
| US-5750702-A | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1998002420-A9 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | — | 1998-04-23 | — | — | WO | disclosed |
| EP-0825193-A1 | Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands | NEUROGEN CORPORATION (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1998002420-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |
| EP-0725775-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011885-A1 | CERTAIN FUSED PYRROLECARBOXANILIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1995-05-04 | — | — | WO | disclosed |