Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396431 | 1.00 | SIGMAR1 (0.42) | SIGMAR1KDM4EALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL7398923 | 1.00 | SIGMAR1 (0.42) | SIGMAR1KDM4EALDH1A1SMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL7395358 | 0.99 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1SMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL7594907 | 0.99 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL7403753 | 0.87 | SIGMAR1 (0.44) | SIGMAR1LTA4HOPRK1OPRM1KCNH2 | |
| Hydrochloric Acid SCHEMBL7397670 | 0.86 | SIGMAR1 (0.43) | SIGMAR1LTA4HOPRK1OPRM1KCNH2 | |
| SCHEMBL7392194 | 0.84 | MAOB (0.44) | LTA4HMAOAMAOB | |
| SCHEMBL7403861 | 0.82 | KMT2A (0.44) | ALDH1A1LTA4HMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7403380 | 0.82 | MAOB (0.43) | LTA4HKCNH2MAOAMAOB | |
| SCHEMBL7367095 | 0.82 | NR5A1 (0.43) | SIGMAR1LTA4HOPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637303-A1 | N-ARYLOXY(THIO)ALKYL-AZACYCLOALKANES USEFUL AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-08 | — | — | EP | claimed |
| WO-1993022302-A1 | N-ARYLOXY(THIO)ALKYL-AZACYCLOALKANES USEFUL AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-11 | — | — | WO | claimed |