SCHEMBL7399889

SCHEMBL7399889

Oc1ccccc1OCCN1CCC(Cc2ccccc2)CC1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TMEM97 Q5BJF2 2/20 0.69
SIGMAR1 Q99720 2/20 0.69
MEN1 O00255 6/20 0.69
KMT2A Q03164 6/20 0.69
KDM4E B2RXH2 4/20 0.69
ALDH1A1 P00352 2/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
NPSR1 Q6W5P4 1/20 0.69
DRD4 P21917 1/20 0.61
MAOB P27338 1/20 0.59
CCR3 P51677 1/20 0.57
PRMT3 O60678 1/20 0.56
CARM1 Q86X55 1/20 0.56
PRMT6 Q96LA8 1/20 0.56
PRMT1 Q99873 1/20 0.56
PRMT8 Q9NR22 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7403750 0.99 TMEM97 (0.67) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL7401909 0.91 KDM4E (0.58) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL7398122 0.90 KDM4E (0.64) TMEM97SIGMAR1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL7407347 0.90 KDM4E (0.57) TMEM97SIGMAR1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL7403706 0.89 KDM4E (0.62) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL5816816 0.85 LTA4H (0.59) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL7398178 0.84 TMEM97 (0.69) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL7402687 0.84 KDM4E (0.72) TMEM97SIGMAR1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL7407391 0.83 TMEM97 (0.67) TMEM97SIGMAR1MEN1KMT2AKDM4E
SCHEMBL5888854 0.82 TMEM97 (1.00) TMEM97SIGMAR1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869792-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-09-22 EP claimed
EP-0869792-A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP claimed
WO-1997023216-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO claimed
US-6124323-A ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
EP-0869792-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-09-22 EP disclosed
EP-0869792-A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP disclosed
WO-1997023216-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed