Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL7400

O=C(O)CCC(=O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 4/20 1.00
▸ OR51E2 Q9H255 2/20 1.00
▸ MAPK1 P28482 1/20 1.00
▸ SLC13A3 Q8WWT9 1/20 1.00
▸ LMNA P02545 6/20 0.64
▸ ALKBH5 Q6P6C2 1/20 0.64
▸ SUCNR1 Q9BXA5 1/20 0.64
▸ SLC15A2 Q16348 1/20 0.47
▸ SLC22A6 Q4U2R8 1/20 0.47
▸ TSHR P16473 2/20 0.44
▸ NFKB1 P19838 1/20 0.44
▸ PMP22 Q01453 1/20 0.44
▸ KDM4E B2RXH2 3/20 0.43
▸ KDM5C P41229 3/20 0.43
▸ PHF8 Q9UPP1 3/20 0.43
▸ KDM2A Q9Y2K7 3/20 0.43
▸ KDM6B O15054 2/20 0.43
▸ FOLH1 Q04609 1/20 0.43
▸ GABRR1 P24046 1/20 0.43
▸ FFAR3 O14843 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Ketoglutaric Acid SCHEMBL30029036 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3776640 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL29783374 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30208560 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL932116 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL17127347 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL6545627 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL2823722 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL4896335 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL20594156 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 45234 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 — — EP claimed
CN-122080382-A Isosorbide type polycarbonate and preparation method thereof — 2026-05-26 — — CN claimed
CN-122081255-A Deep sea source protein fragment and application thereof as penicillin expandase — 2026-05-26 — — CN claimed
CN-122075462-A Application of alpha-ketoglutaric acid in preparation of drugs for enhancing sensitivity of aquatic pathogenic bacteria to florfenicol — 2026-05-26 — — CN claimed
CN-121714774-B Magneto-thermal double-control dynamic energy supply nanomotor nerve graft and preparation method thereof WUHAN UNIVERSITY OF TECHNOLOGY (CN) 2026-05-26 — — CN claimed
WO-2026103747-A1 SALT OF THIAZOLE DERIVATIVE INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 江苏豪森药业集团有限公司 2026-05-21 — — WO claimed
EP-4743461-A1 (S)-1-(1- (3-CHLOROPHENYL)-2-(DIMETHYLAMINO) ETHYL)-4-(5 -MORPHOLINO-1H- PYRROLO[2,3-B]PYRIDIN-3-YL) PYRIDIN-2(1H)-ONE,THEIR PREPARATION AND THEIR USE AS ERK KINASE INHIBITORS AGV Discovery (FR) 2026-05-20 — — EP claimed
EP-3346011-B1 HOST CELLS FOR PREPARING ADIPATE (ESTER OR THIOESTER) GENOMATICA INC (US) 2026-05-20 — — EP claimed
CN-122070278-A Bifunctional protein degradation agent containing aryl substituted heteroaryl and application thereof 标新生物医药科技(上海)有限公司 2026-05-19 — — CN claimed
CN-122060680-A High-activity neural stem cell extracellular vesicle and preparation method and application thereof 上海安库生医生物科技有限公司 2026-05-19 — — CN claimed
EP-0095320-A1 A process for the preparation of beta-lactam compounds BEECHAM GROUP PLC (GB) 1983-11-30 — — EP claimed
EP-0029811-A1 Sheathed surgical suture filament and method for its preparation ASSUT SA (CH) 1981-06-03 — — EP claimed
WO-1981001368-A1 SHEATHED SURGICAL SUTURE FILAMENT AND METHOD FOR ITS PREPARATION BATTELLE MEMORIAL INSTITUTE (CH) 1981-05-28 — — WO claimed
US-4241179-A ENZYME INHIBITORS FOR QUANTITATIVE ANALYSIS COULTER ELECTRONICS, INC. (US) 1980-12-23 — — US claimed
US-4235962-A REAGENTS COMPRISING ASPARATE, ALANINE, 2-OXOGLUTARATE AND REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE THE DOW CHEMICAL COMPANY (US) 1980-11-25 — — US claimed
US-4188465-A GLUTATHIONE, ETHYLENEDIAMINETETRAACETIC ACID, CITRATE BOEHRINGER MANNHEIM GMBH (DE) 1980-02-12 — — US claimed
US-4113850-A SCINTIGRAPHY, TECHNETIUM AND DI- OR TRICARBOXYLIC ACID SOLCO BASEL AG (CH) 1978-09-12 — — US claimed
US-4080263-A Process and reagent for the rapid quantitative determination of lactate or alanine BOEHRINGER MANNHEIM GMBH (DT) 1978-03-21 — — US claimed
US-3978203-A SUSTAINED RELEASE OF PHARMACEUTICALS FROM POLYESTER MATRICES DYNATECH CORPORATION (US) 1976-08-31 — — US claimed
US-3974031-A Process for producing L-cysteine or its derivatives MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) 1976-08-10 — — US claimed
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