Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL932116

O=C(O)CCC(=O)C(=O)O.O=C(O)CCC(=O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 4/20 1.00
▸ OR51E2 Q9H255 2/20 1.00
▸ MAPK1 P28482 1/20 1.00
▸ SLC13A3 Q8WWT9 1/20 1.00
▸ LMNA P02545 6/20 0.64
▸ ALKBH5 Q6P6C2 1/20 0.64
▸ SUCNR1 Q9BXA5 1/20 0.64
▸ SLC15A2 Q16348 1/20 0.47
▸ SLC22A6 Q4U2R8 1/20 0.47
▸ TSHR P16473 2/20 0.44
▸ NFKB1 P19838 1/20 0.44
▸ PMP22 Q01453 1/20 0.44
▸ KDM4E B2RXH2 3/20 0.43
▸ KDM5C P41229 3/20 0.43
▸ PHF8 Q9UPP1 3/20 0.43
▸ KDM2A Q9Y2K7 3/20 0.43
▸ KDM6B O15054 2/20 0.43
▸ FOLH1 Q04609 1/20 0.43
▸ GABRR1 P24046 1/20 0.43
▸ FFAR3 O14843 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Ketoglutaric Acid SCHEMBL30029036 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3776640 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL29783374 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30208560 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL17127347 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL7400 1.00 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL6545627 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL2823722 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL4896335 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL20594156 0.97 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250098726-A1 AEROSOLISABLE MATERIAL Nicoventures Trading Limited (GB) 2025-03-27 — — US claimed
EP-4463019-A1 AEROSOLISABLE MATERIAL Nicoventures Trading Limited (GB) 2024-11-20 — — EP claimed
US-20230363440-A1 PACKAGED FORMULATION NICOVENTURES TRADING LTD (GB) 2023-11-16 — — US claimed
US-20230363441-A1 FORMULATION NICOVENTURES TRADING LTD (GB) 2023-11-16 — — US claimed
WO-2023135408-A1 AEROSOLISABLE MATERIAL Nicoventures Trading Limited (GB) 2023-07-20 — — WO claimed
EP-4203715-A1 PACKAGED FORMULATION Nicoventures Trading Limited (GB) 2023-07-05 — — EP claimed
EP-4203716-A1 FORMULATION Nicoventures Trading Limited (GB) 2023-07-05 — — EP claimed
WO-2022064203-A1 PACKAGED FORMULATION Nicoventures Trading Limited (GB) 2022-03-31 — — WO claimed
WO-2022064204-A1 FORMULATION Nicoventures Trading Limited (GB) 2022-03-31 — — WO claimed
EP-2194143-B1 Phenotype prediction UNIV SOUTHAMPTON (GB) 2016-06-29 — — EP claimed
CN-121574789-A Fermented beverage rich in alpha-ketoglutaric acid and organic acid and preparation method thereof 现代发酵技术研究院(山西)有限公司 2026-02-27 — — CN disclosed
US-20250287987-A1 AEROSOLISABLE MATERIAL Nicoventures Trading Limited (GB) 2025-09-18 — — US disclosed
EP-4609729-A1 AEROSOLISABLE MATERIAL FOR USE IN AN ARTICLE BT DE Investments Inc. (US) 2025-09-03 — — EP disclosed
WO-2025149902-A1 AEROSOLISABLE MATERIAL FOR USE IN AN ARTICLE BT DE Investments Inc. (US) 2025-07-17 — — WO disclosed
WO-2025149897-A1 AEROSOLISABLE MATERIAL FOR USE IN AN ARTICLE BT DE Investments Inc. (US) 2025-07-17 — — WO disclosed
WO-2004028448-A2 METHOD OF ALLEVIATING PAIN VIA INHIBITION OF NEUROTRANSMITTER SYNTHESIS MILLER KENNETH E (US) 2004-04-08 — — WO disclosed
EP-1244775-A1 MOLECULAR DISPLAY ON MULTIMERIC PROTEIN SCAFFOLDS DERIVED FROM THE E2 COMPONENT OF THE ALPHA-KETOACID DEHYDROGENASE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2002-10-02 — — EP disclosed
WO-2001042439-A1 MOLECULAR DISPLAY ON MULTIMERIC PROTEIN SCAFFOLDS DERIVED FROM THE E2 COMPONENT OF THE ALPHA-KETOACID DEHYDROGENASE CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2001-06-14 — — WO disclosed
US-4062652-A Reagent unit intended for microanalyses of standard type and device and method for its production ROLFO FONTANA GUDRUN B 1977-12-13 — — US disclosed
US-3932131-A PHOTOMETRIC MONEGA ANSTALT (FL) 1976-01-13 — — US disclosed
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