Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19817286 | 0.88 | GABBR2 (0.48) | PREPTACR1PDPK1CYP2D6GABBR2 | |
| SCHEMBL3053473 | 0.88 | GABBR2 (0.48) | PREPTACR1PDPK1CYP2D6GABBR2 | |
| SCHEMBL28555786 | 0.85 | PREP (0.44) | PREPTACR1PDPK1CYP2D6GABBR2 | |
| SCHEMBL4778263 | 0.85 | CYP2C19 (0.47) | PREPTACR1PDPK1CYP2D6GABBR2 | |
| Hydrochloric Acid SCHEMBL6557844 | 0.83 | CYP2C19 (0.46) | PREPTACR1PDPK1CYP2D6GABBR2 | |
| SCHEMBL3652941 | 0.80 | KCNA5 (0.47) | CYP2D6LMNA | |
| SCHEMBL1988513 | 0.80 | ESR1 (0.39) | PREPTACR1ESR1ESR2LMNA | |
| SCHEMBL9178718 | 0.78 | TSHR (0.48) | CYP2D6 | |
| SCHEMBL4551819 | 0.77 | PREP (0.44) | PREPCYP2D6GABBR2GABBR1SRC | |
| SCHEMBL27248171 | 0.77 | EPHX1 (0.38) | PREPCYP2D6GABBR2GABBR1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |