Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.83 |
| ▸ | LTA4H | P09960 | 1/20 | 0.81 |
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.70 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.70 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28285426 | 0.91 | HRH3 (0.88) | HRH3LTA4HACHERAD52MEN1 | |
| SCHEMBL7134872 | 0.90 | LTA4H (1.00) | HRH3LTA4HPSMB1PSMB5PSMB2 | |
| SCHEMBL21004113 | 0.89 | HRH3 (0.84) | HRH3LTA4HACHERAD52MEN1 | |
| SCHEMBL8637452 | 0.85 | HRH3 (1.00) | HRH3LTA4HACHERAD52PSMB1 | |
| SCHEMBL11093348 | 0.85 | HRH3 (1.00) | HRH3LTA4HMEN1KMT2A | |
| SCHEMBL7398762 | 0.84 | HRH3 (0.86) | HRH3LTA4HACHERAD52MEN1 | |
| SCHEMBL7142387 | 0.84 | HRH3 (0.97) | HRH3LTA4HACHERAD52PSMB1 | |
| Hydrochloric Acid SCHEMBL7397678 | 0.83 | HRH3 (0.84) | HRH3LTA4HACHERAD52MEN1 | |
| Jnj-5207852 SCHEMBL3577334 | 0.83 | HRH3 (1.00) | HRH3ACHERAD52 | |
| SCHEMBL3572587 | 0.83 | HRH3 (1.00) | HRH3ACHERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869792-A4 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 1999-09-22 | — | — | EP | disclosed |
| EP-0869792-A2 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023216-A1 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |