Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432285 | 0.81 | ITGB3 (0.48) | NAMPTDRD2CCKBRITGB3ITGA2B | |
| SCHEMBL7432277 | 0.81 | ITGB3 (0.48) | NAMPTDRD2CCKBRITGB3ITGA2B | |
| SCHEMBL7441028 | 0.81 | ITGB3 (0.45) | ITGB3ITGA2BITGAVCACNA1GCACNA1H | |
| SCHEMBL7394047 | 0.80 | NAMPT (0.49) | NAMPTDRD2CCKBRITGB3ITGA2B | |
| SCHEMBL6678145 | 0.79 | ITGB3 (0.43) | NAMPTITGB3ITGA2BITGAV | |
| SCHEMBL8401242 | 0.78 | ITGB3 (0.51) | ITGB3ITGA2BITGAV | |
| SCHEMBL8193004 | 0.78 | ITGB3 (0.46) | NAMPTCCKBRITGB3ITGA2BITGAV | |
| SCHEMBL7595444 | 0.77 | ITGB3 (0.70) | NAMPTITGB3ITGA2BITGAV | |
| SCHEMBL7595440 | 0.77 | ITGB3 (0.70) | NAMPTITGB3ITGA2BITGAV | |
| SCHEMBL7338319 | 0.76 | PARP1 (0.44) | ITGB3ITGA2BITGAVMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127359-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0593603-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993000095-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-07 | — | — | WO | disclosed |