Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| T-Butylacetic Acid SCHEMBL7460578 | 0.81 | ACE (0.47) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL7353416 | 0.80 | KDM4E (0.53) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL7400657 | 0.75 | CYP1A2 (0.48) | ACESMN1; SMN2CTSSCTSKHDAC8 | |
| Acetic Acid Methyl Ester SCHEMBL7402646 | 0.74 | KDM4E (0.53) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL314569 | 0.73 | KDM4E (0.55) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL1564513 | 0.73 | KDM4E (0.55) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL5819429 | 0.73 | KDM4E (0.55) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL29604456 | 0.71 | ACE (0.54) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL930665 | 0.71 | ACE (0.68) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL19321588 | 0.71 | HDAC8 (0.47) | ACEKDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790982-B1 | METHODS OF SYNTHESIS OF PEPTIDYL ARGININALS | CORVAS INT INC (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-0765340-B1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5776927-A | THROMBIN INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5731413-A | Method of synthesis of peptidyl aldehydes | CORVAS INTERNATIONAL, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5681844-A | ANTITHROMBOTIC AGENTS, ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| US-5658939-A | PREVENTION THROMBOSIS IN MAMMALS | CORVAS INTERNATIONAL INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5646165-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5514777-A | Methods of synthesis of peptidyl argininals | CORVAS INTERNATIONAL, INC. (US) | 1996-05-07 | — | — | US | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |