SCHEMBL7400657

SCHEMBL7400657

CCCC(CCC)C(=O)N[C@@H](CSCC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.42
PPARG P37231 7/20 0.41
PPARA Q07869 7/20 0.41
CTSS P25774 1/20 0.40
CTSK P43235 1/20 0.40
PPARD Q03181 2/20 0.40
ACE P12821 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7465785 0.82 HDAC8 (0.43) ACEHDAC3HDAC4HDAC1HDAC2
SCHEMBL7353420 0.80 CYP1A2 (0.66) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL7406732 0.77 HDAC8 (0.47) ACEHDAC3HDAC4HDAC1HDAC2
SCHEMBL9066930 0.75 BIRC2 (0.46) CTSSCTSK
SCHEMBL7400654 0.75 ACE (0.45) SMN1; SMN2CTSSCTSKACEHDAC3
SCHEMBL7460583 0.74 ACE (0.41) ACEHDAC3HDAC4HDAC1HDAC2
SCHEMBL7402648 0.73 CYP1A2 (0.64) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL18045098 0.73 CYP1A2 (0.64) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL6484104 0.71 PPARA (0.57) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL21153885 0.71 PPARA (0.57) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0790982-B1 METHODS OF SYNTHESIS OF PEPTIDYL ARGININALS CORVAS INT INC (US) 2002-02-27 EP disclosed
EP-0765340-B1 METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS CORVAS INT INC (US) 2000-08-30 EP disclosed
US-5776927-A THROMBIN INHIBITORS CORVAS INTERNATIONAL, INC. (US) 1998-07-07 US disclosed
US-5731413-A Method of synthesis of peptidyl aldehydes CORVAS INTERNATIONAL, INC. (US) 1998-03-24 US disclosed
US-5681844-A ANTITHROMBOTIC AGENTS, ANTICOAGULANTS CORVAS INTERNATIONAL, INC. (US) 1997-10-28 US disclosed
US-5658939-A PREVENTION THROMBOSIS IN MAMMALS CORVAS INTERNATIONAL INC. (US) 1997-08-19 US disclosed
US-5646165-A ANTITHROMBOTIC AGENTS CORVAS INTERNATIONAL, INC. (US) 1997-07-08 US disclosed
US-5514777-A Methods of synthesis of peptidyl argininals CORVAS INTERNATIONAL, INC. (US) 1996-05-07 US disclosed
WO-1995028420-A1 METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS CORVAS INTERNATIONAL, INC. (US) 1995-10-26 WO disclosed