Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylmethane SCHEMBL27521867 | 0.98 | CALM1 (0.55) | CALM1GBA1MC4RHRH1LTA4H | |
| Diphenylmethane SCHEMBL27486979 | 0.94 | CALM1 (0.50) | CALM1GBA1MC4RHRH1LTA4H | |
| Diphenylmethane SCHEMBL27298666 | 0.83 | CALM1 (0.48) | CALM1GBA1MC4RHRH1LTA4H | |
| Diphenylmethane SCHEMBL27274504 | 0.82 | HRH1 (0.45) | CALM1GBA1HRH1LTA4HSLC6A2 | |
| Diphenylmethane SCHEMBL25402252 | 0.79 | CALM1 (0.92) | CALM1LTA4HIDH1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL10394702 | 0.79 | CALM1 (0.92) | CALM1LTA4HIDH1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL25403056 | 0.79 | CALM1 (0.92) | CALM1LTA4HIDH1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL28958813 | 0.79 | CALM1 (0.92) | CALM1LTA4HIDH1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL29262556 | 0.77 | CALM1 (0.46) | CALM1GBA1MC4RHRH1LTA4H | |
| SCHEMBL19190084 | 0.76 | GBA1 (0.53) | GBA1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104292142-B | A kind of de- aryl method of N- aryl-heterocyclic butane | 天津大地康和医药技术有限公司 | 2019-05-14 | — | — | CN | claimed |
| CN-106905212-A | A kind of process for synthesizing the ketone of 1 dibenzo-p-methyl-aza-cyclobutane 3 | 上海昂提生物科技有限公司 | 2017-06-30 | — | — | CN | claimed |
| CN-104292142-A | Aryl removing method of N-aryl heterocyclic butane | TIANJIN DADI KANGHE MEDICAL TECHNOLOGY CO LTD | 2015-01-21 | — | — | CN | claimed |
| CN-103509003-A | Preparation method of azelnidipine | WEIHAI WEITAI PHARMACEUTICAL TECHNOLOGY DEV CO LTD | 2014-01-15 | — | — | CN | claimed |
| CN-101747249-A | Method for preparing intermediate of azetidine-typed medicaments | UNIV TONGJI | 2010-06-23 | — | — | CN | claimed |
| CN-110437118-A | The preparation method of azaheterocyclic carboxylic acid intermediate and azetidine -3- carboxylic acid | SICHUAN TONGSHENG BIOPHARMACEUTICAL CO LTD | 2019-11-12 | — | — | CN | disclosed |
| CN-104292142-B | A kind of de- aryl method of N- aryl-heterocyclic butane | 天津大地康和医药技术有限公司 | 2019-05-14 | — | — | CN | disclosed |
| CN-104292142-B | A kind of de- aryl method of N- aryl-heterocyclic butane | 天津大地康和医药技术有限公司 | 2019-05-14 | — | — | CN | disclosed |
| CN-109053524-A | A kind of preparation method of N-Boc-3- hydroxy azetidine | 山东谛爱生物技术有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-106905212-A | A kind of process for synthesizing the ketone of 1 dibenzo-p-methyl-aza-cyclobutane 3 | 上海昂提生物科技有限公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-106279109-A | A kind of preparation method of azelnidipine | 威海迪素制药有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-104292142-A | Aryl removing method of N-aryl heterocyclic butane | TIANJIN DADI KANGHE MEDICAL TECHNOLOGY CO LTD | 2015-01-21 | — | — | CN | disclosed |
| CN-1471536-A | chemokine receptor antagonists and methods of use thereof | ǧ��ҩƷ��˾ | 2004-01-28 | — | — | CN | disclosed |
| CN-1455769-A | Cyclic amine sulfonamides as beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | disclosed |
| CN-1179155-A | Heterocyclic compounds | DAIICHI PHARMACEUTICLA CO LTD (JP) | 1998-04-15 | — | — | CN | disclosed |
| EP-0714299-A4 | — | — | 1996-07-10 | — | — | EP | disclosed |
| EP-0714299-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995002405-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-01-26 | — | — | WO | disclosed |
| CN-1017897-B | DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANKYO CO (JP) | 1992-08-19 | — | — | CN | disclosed |
| CN-87107150-A | Dihydrogen pyridine derivative and its production and use | — | 1988-05-04 | — | — | CN | disclosed |