Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.58 |
| ▸ | PDE4A | P27815 | 10/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399841 | 0.84 | PDE5A (0.61) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400772 | 0.76 | PDE5A (0.65) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7432167 | 0.76 | PDE5A (0.79) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7451032 | 0.74 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7440118 | 0.74 | PDE5A (0.72) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7436549 | 0.74 | PDE5A (0.79) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7394813 | 0.73 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7392696 | 0.73 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7389735 | 0.69 | PDE5A (0.69) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7401994 | 0.69 | PDE5A (0.42) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641344-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023401-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-25 | — | — | WO | disclosed |