Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.42 |
| ▸ | PDE4A | P27815 | 19/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395398 | 0.88 | PDE5A (0.49) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7399841 | 0.85 | PDE5A (0.61) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400643 | 0.74 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400772 | 0.73 | PDE5A (0.65) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7432167 | 0.59 | PDE5A (0.79) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400872 | 0.59 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400585 | 0.57 | PDE4A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7436549 | 0.57 | PDE5A (0.79) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9350760 | 0.57 | PDE4A (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7493467 | 0.57 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993023401-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-25 | — | — | WO | disclosed |