Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
| ▸ | UGCG | Q16739 | 2/20 | 0.32 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238273 | 1.00 | PRMT5 (0.43) | PRMT5WDR77USP2SLC1A3SLC1A2 | |
| SCHEMBL21402622 | 0.98 | PRMT5 (0.46) | PRMT5WDR77USP2SLC1A3SLC1A2 | |
| SCHEMBL21810996 | 0.91 | USP2 (0.44) | PRMT5WDR77USP2LMNAALDH1A1 | |
| SCHEMBL8737334 | 0.86 | USP2 (0.40) | PRMT5WDR77USP2LMNAALDH1A1 | |
| SCHEMBL9652887 | 0.86 | USP2 (0.40) | PRMT5WDR77USP2LMNAALDH1A1 | |
| SCHEMBL3893240 | 0.83 | USP2 (0.36) | PRMT5WDR77USP2 | |
| SCHEMBL21402614 | 0.82 | USP2 (0.42) | PRMT5WDR77USP2LMNAALDH1A1 | |
| SCHEMBL24729200 | 0.79 | PRMT5 (0.44) | PRMT5WDR77LMNA | |
| SCHEMBL13459004 | 0.79 | USP2 (0.46) | PRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL13459028 | 0.77 | USP2 (0.49) | USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |