Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876173 | 0.89 | AAK1 (0.50) | AAK1KMT2AKDM4ETSHRMEN1 | |
| SCHEMBL10207290 | 0.86 | AAK1 (0.45) | AAK1KMT2AKDM4EMEN1AKT1 | |
| SCHEMBL894847 | 0.86 | AAK1 (0.70) | AAK1GAAKMT2AKDM4ETSHR | |
| SCHEMBL10166817 | 0.86 | AAK1 (0.70) | AAK1GAAKMT2AKDM4ETSHR | |
| SCHEMBL7539409 | 0.84 | AAK1 (0.56) | AAK1GAAKMT2AMIFTSHR | |
| SCHEMBL19055964 | 0.84 | AAK1 (0.46) | AAK1KMT2AKDM4ETSHRMEN1 | |
| SCHEMBL7546027 | 0.83 | AAK1 (0.54) | AAK1GAAKMT2AMIFTSHR | |
| SCHEMBL12091642 | 0.80 | AAK1 (0.50) | AAK1GAAKMT2AMIFTSHR | |
| SCHEMBL12087979 | 0.80 | AAK1 (0.50) | AAK1GAAKMT2AMIFTSHR | |
| SCHEMBL12564392 | 0.79 | AAK1 (0.67) | AAK1KMT2AKDM4ETSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |