Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132790 | 0.97 | ALOX15 (0.46) | ALOX15ALDH1A1LMNANPSR1PSEN1 | |
| SCHEMBL7398911 | 0.91 | ALOX15 (0.51) | ALOX15ALDH1A1LMNANPSR1PSEN1 | |
| SCHEMBL7401038 | 0.77 | NPC1 (0.39) | ALOX15ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7402718 | 0.74 | ALOX15 (0.60) | ALOX15ALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL7394496 | 0.72 | PTPN1 (0.36) | ALOX15ALDH1A1LMNANPSR1PSEN1 | |
| SCHEMBL7400017 | 0.72 | ALOX15 (0.53) | ALOX15ALDH1A1LMNANPSR1PKM | |
| SCHEMBL7402017 | 0.71 | HDAC3 (0.40) | ALDH1A1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL17221355 | 0.65 | MEN1 (0.43) | ALDH1A1LMNANPSR1PSEN1PSEN2 | |
| SCHEMBL7395406 | 0.65 | HDAC3 (0.41) | ALDH1A1LMNAMEN1KMT2AHDAC3 | |
| SCHEMBL13515779 | 0.64 | NPC1 (0.58) | ALDH1A1NPSR1MEN1KMT2ATNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650484-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5559105-A | ANTAGONIST FOR ENDOTHELIN RECEPTORS, HYPOTENSIVE AGENTS, TREATMENT OF KIDNEY FAILURE OR CEREBROVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0650484-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994002474-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-02-03 | — | — | WO | disclosed |