Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395413 | 0.95 | MAPT (0.43) | LMNAMAPTTP53TNFNAMPT | |
| SCHEMBL7400472 | 0.92 | MAPT (0.39) | LMNAMAPTTP53TNFNAMPT | |
| SCHEMBL7405127 | 0.87 | MAPT (0.42) | LMNAMAPTTP53TNFNAMPT | |
| SCHEMBL7404205 | 0.84 | TNF (0.40) | MAPTTNFSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7401659 | 0.84 | BRD4 (0.51) | TNFALDH1A1BRD4 | |
| SCHEMBL7397188 | 0.81 | MAOB (0.48) | TNFRAB9AKMT2A | |
| SCHEMBL7328382 | 0.79 | ITGB3 (0.47) | LMNAMAPTTP53NAMPTITGB3 | |
| SCHEMBL7400118 | 0.76 | TNF (0.48) | LMNATP53TNFALDH1A1HPGD | |
| SCHEMBL7445163 | 0.76 | MEN1 (0.56) | TNFBRD4KMT2A | |
| SCHEMBL7397044 | 0.76 | TNF (0.39) | LMNAMAPTTNFSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716951-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5705890-A | PLATELET AGGREGATION INHIBITOR, ANTITHROMBOTIC | GENENTECH, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5493020-A | ANTICOAGULANTS | GENENTECH, INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |