Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 15/20 | 0.64 |
| ▸ | ITGAV | P06756 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399713 | 0.93 | ITGB3 (0.54) | ITGB3ITGA2BYAP1 | |
| SCHEMBL8603766 | 0.86 | ITGB3 (0.64) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7398105 | 0.84 | ACACB (0.49) | ITGB3ITGA2BYAP1 | |
| SCHEMBL8640149 | 0.84 | ITGB3 (0.60) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7400369 | 0.83 | ITGB3 (0.67) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7398960 | 0.82 | ITGB3 (0.71) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7404574 | 0.82 | ITGB3 (0.64) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL8604265 | 0.80 | ITGB3 (0.56) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL8636830 | 0.80 | ITGB3 (0.62) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7395043 | 0.79 | ITGB3 (0.53) | ITGB3ITGA2BITGAVCHRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691959-B1 | HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | ZENECA LTD (GB) | 1998-07-22 | — | — | EP | disclosed |
| EP-0825184-A1 | Heterocyclic derivatives as platelet aggregation inhibitors | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5652242-A | 3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BURYIC ACID, AMIDE OR ESTER; INHIBITORS OF BINDING OF FIBRINOGEN TO GLYCOPROTEIN | ZENECA LIMITED (GB) | 1997-07-29 | — | — | US | disclosed |
| US-5563141-A | INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| US-5556977-A | ANTIAGGLOMERANTS FOR CELLS, ANTICOAGULANTS, ANTIISCHEMIC AGENTS USING PYRIDINYLPIPERAZINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-09-17 | — | — | US | disclosed |
| EP-0690847-A1 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022835-A2 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |