Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.43 |
| ▸ | PEPD | P12955 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967382 | 0.99 | SMYD3 (0.48) | SMYD3FKBP1APEPDGAAPSEN1 | |
| SCHEMBL5967034 | 0.98 | SMYD3 (0.49) | SMYD3FKBP1APEPDGAAPSEN1 | |
| SCHEMBL7401797 | 0.85 | PSEN1 (0.41) | SMYD3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5967094 | 0.83 | ACE (0.52) | FKBP1AKLK5ACE | |
| SCHEMBL5967019 | 0.77 | PSEN1 (0.46) | SMYD3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5967239 | 0.77 | SMYD3 (0.45) | SMYD3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15584468 | 0.75 | FKBP1A (0.48) | FKBP1APEPDKMT2AKLK5XPNPEP1 | |
| SCHEMBL30674429 | 0.75 | ACE (0.50) | FKBP1AKMT2AACE | |
| SCHEMBL22209461 | 0.74 | CCR1 (0.52) | FKBP1AKLK5ACE | |
| SCHEMBL5966976 | 0.74 | SMYD3 (0.55) | SMYD3PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | claimed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |