Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | HRH1 | P35367 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740285 | 1.00 | DPP4 (0.55) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL739483 | 0.92 | CNR2 (0.48) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL739481 | 0.92 | CNR2 (0.48) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL738833 | 0.92 | HRH1 (0.49) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL738834 | 0.92 | HRH1 (0.49) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL740546 | 0.91 | DPP4 (0.44) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL740174 | 0.91 | KCNH2 (0.47) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL740547 | 0.91 | DPP4 (0.44) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL740173 | 0.91 | KCNH2 (0.47) | DPP4DPP8KCNH2HRH1CYP2D6 | |
| SCHEMBL741961 | 0.91 | HRH1 (0.45) | DPP4DPP8KCNH2HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |