Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740546 | 1.00 | DPP4 (0.44) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL741961 | 0.92 | HRH1 (0.45) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL741962 | 0.92 | HRH1 (0.45) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL742023 | 0.92 | DPP4 (0.43) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL742022 | 0.92 | DPP4 (0.43) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL740285 | 0.91 | DPP4 (0.55) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL740286 | 0.91 | DPP4 (0.55) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL738833 | 0.91 | HRH1 (0.49) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL738834 | 0.91 | HRH1 (0.49) | DPP4DPP8HRH1KCNH2CYP2D6 | |
| SCHEMBL741848 | 0.89 | KCNH2 (0.45) | DPP4HRH1KCNH2CYP2D6PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |