Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.59 |
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109777 | 0.78 | DRD3 (0.50) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL8094393 | 0.77 | DRD3 (0.55) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL8688812 | 0.76 | DRD3 (1.00) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL7452274 | 0.72 | FYN (0.58) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL8689700 | 0.71 | DRD3 (0.55) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL29605342 | 0.71 | DRD3 (0.55) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL7411601 | 0.71 | DRD3 (0.48) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL8693035 | 0.71 | FYN (0.70) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL7405339 | 0.70 | FYN (0.64) | DRD3DRD2FYNALDH1A1CYP2D6 | |
| SCHEMBL16299407 | 0.70 | DRD3 (0.85) | DRD3DRD2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |