SCHEMBL7411601

SCHEMBL7411601

CCCN(CCC)C1Cc2cc3c(cc2C1)C(=O)N(Cc1ccccc1)C3

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 4/20 0.48
ALDH1A1 P00352 2/20 0.46
GAA P10253 1/20 0.46
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.46
HTR1A P08908 4/20 0.45
DRD2 P14416 2/20 0.43
FYN P06241 1/20 0.43
DRD4 P21917 1/20 0.43
HTR7 P34969 2/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7449696 0.90 DRD3 (0.47) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL7407181 0.89 FYN (0.41) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL7408451 0.87 DRD2 (0.42) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL7457771 0.86 FNTA (0.40) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL8094410 0.84 GRM2 (0.41) DRD3ALDH1A1TSHRHTR1ADRD2
SCHEMBL8103965 0.83 ALDH1A1 (0.55) DRD3ALDH1A1GAATSHRHSD17B10
SCHEMBL8109777 0.81 DRD3 (0.50) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL7404669 0.78 FYN (0.51) DRD3ALDH1A1HTR1ADRD2FYN
SCHEMBL7451070 0.77 DRD2 (0.50) DRD3ALDH1A1GAATSHRHSD17B10
SCHEMBL8094393 0.76 DRD3 (0.55) DRD3ALDH1A1HTR1ADRD2FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6084130-A FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS PHARMACIA & UPJOHN COMPANY (US) 2000-07-04 US disclosed
EP-0923542-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1999-06-23 EP disclosed
WO-1997045403-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1997-12-04 WO disclosed