Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400118 | 0.89 | TNF (0.48) | TNFPDGFRBKDRLRRK2KAT2B | |
| SCHEMBL7405133 | 0.85 | TNF (0.45) | TNFALDH1A1 | |
| SCHEMBL9051820 | 0.85 | KDM4E (0.46) | PDGFRBKDRLRRK2ALDH1A1TP53 | |
| SCHEMBL7397044 | 0.78 | TNF (0.39) | TNFALDH1A1MAPTLMNA | |
| SCHEMBL7325381 | 0.78 | ITGB3 (0.46) | TNFKAT2BALDH1A1PIN1PIN4 | |
| SCHEMBL7405127 | 0.77 | MAPT (0.42) | TNFLRRK2ALDH1A1MAPTTP53 | |
| SCHEMBL7400472 | 0.77 | MAPT (0.39) | TNFALDH1A1MAPTTP53LMNA | |
| SCHEMBL7445163 | 0.77 | MEN1 (0.56) | TNFPDGFRBKDRLRRK2 | |
| SCHEMBL7405808 | 0.76 | BRD4 (0.49) | TNFALDH1A1 | |
| SCHEMBL7332719 | 0.73 | TNF (0.47) | TNFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716951-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5705890-A | PLATELET AGGREGATION INHIBITOR, ANTITHROMBOTIC | GENENTECH, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5493020-A | ANTICOAGULANTS | GENENTECH, INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |