Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.85 |
| ▸ | DRD4 | P21917 | 6/20 | 0.73 |
| ▸ | DRD2 | P14416 | 5/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.67 |
| ▸ | HTR2A | P28223 | 4/20 | 0.67 |
| ▸ | HRH2 | P25021 | 3/20 | 0.63 |
| ▸ | HRH1 | P35367 | 3/20 | 0.63 |
| ▸ | DRD1 | P21728 | 3/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 2/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.63 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.63 |
| ▸ | DRD5 | P21918 | 2/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414308 | 0.90 | HRH4 (0.82) | HRH4DRD4DRD2ADRA2AHTR2A | |
| Isoloxapine SCHEMBL2738975 | 0.84 | HRH4 (1.00) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL7410631 | 0.83 | HRH4 (0.84) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL7404974 | 0.82 | HRH4 (0.82) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL9216773 | 0.81 | DRD4 (1.00) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL2615392 | 0.79 | HRH4 (0.78) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL11505616 | 0.78 | HRH4 (0.74) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL7415170 | 0.78 | HRH4 (0.71) | HRH4DRD4DRD2ADRA2AHTR2A | |
| SCHEMBL3408030 | 0.77 | HTR2A (0.65) | HRH4DRD4DRD2ADRA2AHTR2A | |
| Loxapine SCHEMBL19386241 | 0.77 | HRH4 (1.00) | HRH4DRD4DRD2ADRA2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3962248-A | PROCESS FOR MAKING 11-PIPERAZINO-DIAZEPINES, OXAZEPINES, THIAZEPINES AND AZEPINES | SANDOZ, INC. (US) | 1976-06-08 | — | — | US | disclosed |