SCHEMBL7404606

SCHEMBL7404606

C(#CCN1CCC(Oc2ccccc2)CC1)Cc1cc[c]cc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.48
CARM1 Q86X55 1/20 0.46
PRMT6 Q96LA8 1/20 0.46
DRD2 P14416 4/20 0.43
DRD4 P21917 4/20 0.43
DRD3 P35462 3/20 0.43
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
OPRK1 P41145 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39
HTR7 P34969 2/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
HTR2A P28223 1/20 0.38
NR3C1 P04150 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7445090 0.91 HRH3 (0.53) HRH3CARM1PRMT6DRD2DRD4
SCHEMBL7403298 0.80 GRIN1 (0.58) LMNAHTT
SCHEMBL7401042 0.78 BCHE (0.46) CARM1PRMT6SMN1; SMN2
SCHEMBL1307520 0.77 HRH3 (0.58) HRH3CARM1PRMT6DRD2DRD4
SCHEMBL1895869 0.76 HRH3 (0.69) HRH3CARM1PRMT6GAASMN1; SMN2
SCHEMBL19207211 0.76 HRH3 (0.52) HRH3CARM1PRMT6DRD2DRD4
SCHEMBL7405750 0.74 HRH1 (0.42) HRH3HTR7LMNAHTR2A
SCHEMBL5544898 0.72 FFAR4 (0.53) HRH3CARM1PRMT6DRD2DRD4
SCHEMBL7103194 0.71 HRH3 (0.60) HRH3CARM1PRMT6DRD2DRD4
SCHEMBL4855546 0.70 HRH3 (0.74) HRH3CARM1PRMT6DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869791-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-04-28 EP disclosed
EP-0869791-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP disclosed
WO-1997023214-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed