Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571076 | 0.91 | PTGER4 (0.46) | PTGER4EGLN2KAT2BMAPTLMNA | |
| SCHEMBL763192 | 0.84 | KAT2B (0.43) | KAT2BMAPTALDH1A1KDM4EGAA | |
| SCHEMBL29484071 | 0.80 | KDM4E (0.41) | KAT2BLMNAALDH1A1KDM4EGAA | |
| SCHEMBL14421587 | 0.80 | KDM4E (0.41) | KAT2BLMNAALDH1A1KDM4EGAA | |
| SCHEMBL24320215 | 0.79 | PTGER4 (0.56) | PTGER4EGLN2KAT2BMAPTLMNA | |
| SCHEMBL8252221 | 0.79 | KAT2B (0.42) | KAT2BMAPTALDH1A1KDM4EGAA | |
| SCHEMBL8317776 | 0.79 | PTGER4 (0.51) | PTGER4KAT2BMAPTLMNAALDH1A1 | |
| SCHEMBL763898 | 0.79 | PTGER4 (0.48) | PTGER4MAPTALDH1A1KDM4EGAA | |
| SCHEMBL3775668 | 0.78 | PTGER4 (0.47) | PTGER4MAPTLMNANCF1ALDH1A1 | |
| SCHEMBL742145 | 0.78 | PTGER4 (0.47) | PTGER4MAPTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |