Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740525 | 1.00 | HRH1 (0.41) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL740424 | 0.96 | HRH1 (0.41) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL740423 | 0.96 | HRH1 (0.41) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL762743 | 0.93 | HRH1 (0.41) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL739437 | 0.92 | HRH1 (0.40) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL741804 | 0.91 | HRH1 (0.40) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL741803 | 0.91 | HRH1 (0.40) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL763245 | 0.89 | HRH1 (0.42) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL16301226 | 0.89 | HRH1 (0.38) | HRH1CYP2D6MAPK1KCNH2CHRM1 | |
| SCHEMBL740939 | 0.89 | BTK (0.41) | HRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |