2-Thiophenenecarboxaldehyde

2-Thiophenenecarboxaldehyde

SCHEMBL7405336

CCOC(C)OCC.O=Cc1cccs1.OCCO

nearest known ligand 0.41

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.39
HPGD P15428 1/20 0.39
MAPT P10636 6/20 0.39
MAPK1 P28482 2/20 0.39
ALDH1A1 P00352 3/20 0.37
LMNA P02545 3/20 0.37
TAS1R3 Q7RTX0 2/20 0.37
TAS1R1 Q7RTX1 2/20 0.37
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
BLM P54132 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
CYP1A2 P05177 1/20 0.36
RECQL P46063 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Thiophenenecarboxaldehyde SCHEMBL28578457 0.82 HCAR2 (0.47) SMN1; SMN2HPGDMAPTALDH1A1LMNA
SCHEMBL10349965 0.76 SMN1; SMN2 (0.39) SMN1; SMN2HPGDMAPTMAPK1ALDH1A1
SCHEMBL10349963 0.76 SMN1; SMN2 (0.39) SMN1; SMN2HPGDMAPTMAPK1ALDH1A1
Benzaldehyde SCHEMBL4954589 0.75 ALDH1A1 (0.47) ALDH1A1LMNANPC1KMT2AMEN1
2-Thiophenenecarboxaldehyde SCHEMBL7346022 0.73 MAPT (0.46) SMN1; SMN2HPGDMAPTALDH1A1LMNA
2-Thiophenenecarboxaldehyde SCHEMBL31206 0.73
2-Thiophenenecarboxaldehyde SCHEMBL8840818 0.73 SMN1; SMN2 (0.54) SMN1; SMN2HPGDMAPTALDH1A1LMNA
2-Thiophenenecarboxaldehyde SCHEMBL27772563 0.72 MAPT (0.50) SMN1; SMN2HPGDMAPTALDH1A1LMNA
Salicyladehyde SCHEMBL23044726 0.72 TRIM24 (0.55) SMN1; SMN2HPGDMAPTALDH1A1LMNA
2-Thiophenenecarboxaldehyde SCHEMBL29189095 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714295-B1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2000-12-20 EP disclosed
EP-0714295-A4 1996-07-10 EP disclosed
EP-0714295-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1996-06-05 EP disclosed
US-5397791-A Anticoagulants MERCK & CO., INC. (US) 1995-03-14 US disclosed
WO-1995004531-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-02-16 WO disclosed