Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.57 |
| ▸ | LOX | P28300 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407077 | 0.77 | POLB (0.64) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL124721 | 0.77 | GAA (0.65) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| Edaravone SCHEMBL4704 | 0.77 | KMT2A (1.00) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7400667 | 0.77 | GAA (0.62) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11729834 | 0.76 | MEN1 (0.61) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL2604371 | 0.76 | MEN1 (0.74) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3408946 | 0.74 | POLB (1.00) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL6757713 | 0.73 | MEN1 (0.63) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL5976227 | 0.73 | GAA (0.62) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8615912 | 0.73 | GAA (0.57) | GAAKMT2AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |