Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406279 | 1.00 | MMP9 (0.47) | MMP9MMP8MMP14MEN1KMT2A | |
| SCHEMBL10758642 | 0.88 | PTPN1 (0.59) | KMT2APTPN1ALDH1A1RAB9APSMB5 | |
| SCHEMBL10758650 | 0.88 | PTPN1 (0.59) | KMT2APTPN1ALDH1A1RAB9APSMB5 | |
| SCHEMBL10758814 | 0.83 | ACE (0.61) | KMT2A | |
| SCHEMBL10758805 | 0.83 | ACE (0.61) | KMT2A | |
| SCHEMBL7289252 | 0.80 | PTPN1 (0.56) | MEN1KMT2APTPN1L3MBTL1ALDH1A1 | |
| SCHEMBL4524389 | 0.78 | UBE2N (0.59) | MMP9MMP8MMP14L3MBTL1RAB9A | |
| SCHEMBL25410860 | 0.77 | MMP9 (0.73) | MMP9MMP8MMP14L3MBTL1RAB9A | |
| SCHEMBL24414099 | 0.77 | MMP9 (0.73) | MMP9MMP8MMP14L3MBTL1RAB9A | |
| SCHEMBL10656740 | 0.77 | ACE (0.56) | KMT2APTPN1RAB9APSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013861-A | Chemical intermediates for hypotensive agents, inhibitors of angiotensin converting enzyme | E. R. SQUIBB & SONS, INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-H725-H | Ureido amino and imino acids, compositions and methods for use | E. R. SQUIBB & SONS, INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4818757-A | HYPOTENSIVE AGENTS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1989-04-04 | — | — | US | disclosed |
| US-4810791-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| US-4740508-A | HYPOTENSIVE AGENTS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1988-04-26 | — | — | US | disclosed |
| US-4638010-A | HYPOTENSIVE, ENZYME INHIBITORS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1987-01-20 | — | — | US | disclosed |
| EP-0202776-A1 | Ureidoalkanoylaminocarbonyl amino and imino acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-11-26 | — | — | EP | disclosed |