Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187066 | 0.89 | SYK (0.55) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL2061787 | 0.89 | SYK (0.55) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL2062558 | 0.89 | SYK (0.55) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL12203687 | 0.83 | SYK (0.58) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL8972112 | 0.83 | SYK (0.58) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL2775895 | 0.81 | PPARA (0.57) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL1143898 | 0.81 | PPARA (0.57) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL29398102 | 0.81 | SYK (0.57) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL478289 | 0.81 | PPARA (0.57) | SYKCTSKCTSLCTSBCTSS | |
| SCHEMBL12798896 | 0.81 | SYK (0.57) | SYKCTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076968-A1 | MALONATES AS INHIBITORS OF THE ICE/CED-6 FAMILY OF CYSTEINE PROTEASES | NOVARTIS AG (CH) | 2002-10-03 | — | — | WO | disclosed |
| WO-2002034751-A1 | HEXAHYDRO-4-OXOAZEPINO[3,2,1-HI]INDOLES | NOVARTIS AG (CH) | 2002-05-02 | — | — | WO | disclosed |