Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 9/20 | 0.52 |
| ▸ | F10 | P00742 | 9/20 | 0.52 |
| ▸ | F7 | P08709 | 3/20 | 0.52 |
| ▸ | PLAU | P00749 | 9/20 | 0.49 |
| ▸ | PLG | P00747 | 8/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.49 |
| ▸ | PLAT | P00750 | 5/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548406 | 0.84 | F2 (0.58) | F2F10F7PLAUPLG | |
| Hydrochloric Acid SCHEMBL29202497 | 0.82 | F2 (0.68) | F2F10F7PLAUPLG | |
| SCHEMBL7409967 | 0.79 | F10 (0.60) | F2F10F7PLAUPLG | |
| SCHEMBL7879342 | 0.79 | PLAU (0.65) | F2F10F7PLAUPLG | |
| Hydrochloric Acid SCHEMBL11298806 | 0.79 | PLAU (0.65) | F2F10F7PLAUPLG | |
| SCHEMBL6753170 | 0.78 | F2 (0.56) | F2F10F7PLAUPLG | |
| SCHEMBL23793907 | 0.77 | F2 (0.83) | AURKBF2F10F7PLAU | |
| SCHEMBL5303225 | 0.76 | F10 (0.50) | F2F10F7PLAUPLG | |
| SCHEMBL8162910 | 0.76 | F2 (0.56) | F2F10F7PLAUPLG | |
| SCHEMBL2077857 | 0.76 | F2 (0.60) | F2F10F7PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150379-A | BLOOD COAGULATION FACTOR XA INHIBITORS; TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE ACTIVITY; THROMBOLYTIC AND ISCHEMIC AGENTS; E.G., 2-(6-(5-AMIDINO-1H-BENZIMIDAZOL-2-YL)-PYRID-3-YLCARBONYLAMINO)-3 -HYDROXYBUTYRIC ACID | AXYS PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999026941-A1 | SUBSTITUTED AMIDINOARYL DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |