Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399430 | 0.90 | TMEM97 (0.63) | TMEM97SIGMAR1MAOBKDM4EMEN1 | |
| SCHEMBL7406544 | 0.83 | MEN1 (0.53) | TMEM97SIGMAR1MAOBKDM4EMEN1 | |
| SCHEMBL7403499 | 0.82 | TMEM97 (0.73) | TMEM97SIGMAR1MAOBKDM4EMEN1 | |
| SCHEMBL6005396 | 0.82 | L3MBTL1 (0.62) | KDM4ENPSR1KCNH2 | |
| SCHEMBL7406645 | 0.82 | TMEM97 (0.59) | TMEM97SIGMAR1MAOBKDM4EMEN1 | |
| SCHEMBL7247107 | 0.80 | KCNH2 (0.61) | TMEM97SIGMAR1KDM4EKCNH2 | |
| SCHEMBL7401219 | 0.80 | TMEM97 (0.68) | TMEM97SIGMAR1MAOBKDM4EMEN1 | |
| Bromide SCHEMBL7247104 | 0.79 | KCNH2 (0.60) | TMEM97SIGMAR1KDM4EKCNH2 | |
| SCHEMBL7403890 | 0.78 | TMEM97 (0.76) | TMEM97SIGMAR1MAOBMEN1KMT2A | |
| SCHEMBL7402782 | 0.78 | TMEM97 (0.76) | TMEM97SIGMAR1MAOBHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869792-A4 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 1999-09-22 | — | — | EP | disclosed |
| EP-0869792-A2 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023216-A1 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |