Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408723 | 1.00 | POLB (0.47) | POLBALDH1A1MAPTLTA4HHPGD | |
| SCHEMBL7406748 | 1.00 | POLB (0.47) | POLBALDH1A1MAPTLTA4HHPGD | |
| SCHEMBL7407929 | 0.95 | POLB (0.54) | POLBALDH1A1MAPTLTA4HHPGD | |
| SCHEMBL7418424 | 0.95 | POLB (0.54) | POLBALDH1A1MAPTLTA4HHPGD | |
| SCHEMBL7406856 | 0.95 | POLB (0.54) | POLBALDH1A1MAPTLTA4HHPGD | |
| Hydrochloric Acid SCHEMBL7419292 | 0.94 | POLB (0.53) | POLBALDH1A1MAPTLTA4HHPGD | |
| SCHEMBL7414863 | 0.84 | LTA4H (0.43) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL7414870 | 0.84 | LTA4H (0.43) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL11448868 | 0.83 | POLB (0.50) | POLBLTA4HCHRNB4CHRNA3HTR6 | |
| Hydrochloric Acid SCHEMBL7416892 | 0.83 | LTA4H (0.43) | LTA4HCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734379-B1 | 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | PARKE DAVIS (FR) | 2001-03-07 | — | — | EP | disclosed |
| EP-0995436-A2 | Ligands for sigma receptors and their therapeutical applications | PARKE-DAVIS (FR) | 2000-04-26 | — | — | EP | disclosed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| US-5849760-A | 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1998-12-15 | — | — | US | disclosed |
| EP-0734379-A1 | NOVEL 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995015948-A1 | NOVEL 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1995-06-15 | — | — | WO | disclosed |