Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.39 |
| ▸ | F2 | P00734 | 6/20 | 0.39 |
| ▸ | PLG | P00747 | 4/20 | 0.39 |
| ▸ | PROC | P04070 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411701 | 0.94 | F10 (0.40) | F10PRSS1F2PLGPROC | |
| SCHEMBL7408430 | 0.91 | F10 (0.48) | F10PRSS1F2PLGPROC | |
| SCHEMBL7408558 | 0.91 | F10 (0.48) | F10PRSS1F2PLGPROC | |
| SCHEMBL7408226 | 0.90 | F10 (0.47) | F10PRSS1F2PLGPROC | |
| SCHEMBL7412299 | 0.86 | HDAC3 (0.34) | F10PRSS1F2PLGPROC | |
| SCHEMBL7415903 | 0.85 | F10 (0.56) | F10PRSS1F2PLGPROC | |
| SCHEMBL7411988 | 0.84 | F10 (0.46) | F10PRSS1F2PLGPROC | |
| SCHEMBL7410658 | 0.83 | F10 (0.43) | F10PRSS1F2PLGPROC | |
| SCHEMBL7403848 | 0.83 | F10 (0.42) | F10PRSS1F2PLGPROC | |
| SCHEMBL7124172 | 0.82 | F10 (0.56) | F10PRSS1F2PLGPROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068191-A1 | BENZOXAZINONES/BENZOTHIAZINONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999050257-A1 | BENZOXAZINONES/BENZOTHIAZINONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | claimed |
| EP-1068191-A1 | BENZOXAZINONES/BENZOTHIAZINONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999050257-A1 | BENZOXAZINONES/BENZOTHIAZINONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |