SCHEMBL7407647

SCHEMBL7407647

CCCN(CCC)[C@@H]1CCc2ccc(C(N)=O)cc2C1

nearest known ligand 0.71

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 11/20 0.71
DRD2 P14416 10/20 0.66
DRD4 P21917 4/20 0.66
HTR1A P08908 4/20 0.66
MEN1 O00255 2/20 0.66
KMT2A Q03164 2/20 0.66
ADRB2 P07550 1/20 0.66
CYP2D6 P10635 1/20 0.66
CASP1 P29466 1/20 0.66
LMNA P02545 2/20 0.64
MAPT P10636 1/20 0.64
FYN P06241 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7407655 1.00 DRD3 (0.71) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752127 0.99 DRD3 (0.70) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752125 0.99 DRD3 (0.70) DRD3DRD2DRD4HTR1AMEN1
SCHEMBL9752126 0.89 DRD3 (0.61) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752131 0.89 DRD3 (0.59) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752128 0.89 DRD3 (0.59) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752136 0.87 DRD3 (0.69) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752122 0.84 DRD3 (0.62) DRD3DRD2DRD4HTR1AMEN1
Hydrochloric Acid SCHEMBL9752124 0.83 DRD3 (0.60) DRD3DRD2DRD4HTR1AMEN1
SCHEMBL8057491 0.82 DRD2 (0.82) DRD3DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6084130-A FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS PHARMACIA & UPJOHN COMPANY (US) 2000-07-04 US disclosed
EP-0923542-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1999-06-23 EP disclosed
WO-1997045403-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1997-12-04 WO disclosed