Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 16/20 | 0.54 |
| ▸ | DRD2 | P14416 | 15/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408200 | 1.00 | DRD3 (0.54) | DRD3DRD2CYP19A1DRD4MEN1 | |
| SCHEMBL7861583 | 0.92 | CYP19A1 (0.54) | DRD3DRD2CYP19A1 | |
| SCHEMBL7457363 | 0.87 | DRD3 (0.61) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7457371 | 0.87 | DRD3 (0.61) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7402836 | 0.85 | DRD3 (0.54) | DRD3DRD2CYP19A1DRD4MEN1 | |
| SCHEMBL7402838 | 0.85 | DRD3 (0.54) | DRD3DRD2CYP19A1DRD4MEN1 | |
| SCHEMBL8094252 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL8094256 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7411286 | 0.83 | DRD3 (0.67) | DRD3DRD2 | |
| SCHEMBL7411290 | 0.83 | DRD3 (0.67) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |