Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.54 |
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094256 | 1.00 | DRD3 (0.54) | DRD3DRD2HTR2AHTR2CHTR6 | |
| SCHEMBL7405930 | 0.87 | DRD3 (0.55) | DRD3DRD2HTR2AHTR2CHTR6 | |
| SCHEMBL7405925 | 0.87 | DRD3 (0.55) | DRD3DRD2HTR2AHTR2CHTR6 | |
| SCHEMBL7408200 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7408204 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL4112328 | 0.82 | DRD3 (0.55) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL4119788 | 0.82 | DRD3 (0.55) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL4112321 | 0.82 | DRD3 (0.55) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL9776785 | 0.82 | DRD3 (0.62) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL9752129 | 0.81 | DRD2 (0.65) | DRD3DRD2DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |