SCHEMBL7408208

SCHEMBL7408208

COc1cc2c(cc1OC)C(c1cccc(Cl)c1)=NNC(=O)C2

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.66
CYP3A4 P08684 1/20 0.66
CYP2C9 P11712 1/20 0.66
MAPK1 P28482 1/20 0.66
CYP2C19 P33261 1/20 0.66
MAPK10 P53779 5/20 0.59
MAPK14 Q16539 2/20 0.51
MAPK9 P45984 1/20 0.51
TDP2 O95551 2/20 0.45
PDE7A Q13946 1/20 0.44
PDE3A Q14432 1/20 0.44
PDE10A Q9Y233 1/20 0.44
PDGFRB P09619 1/20 0.43
GRIA2 P42262 2/20 0.43
EIF2AK1 Q9BQI3 1/20 0.42
SLC2A1 P11166 1/20 0.42
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
PGR P06401 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7409537 0.88 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7409065 0.88 CYP1A2 (0.51) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7411882 0.87 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7405387 0.87 CYP1A2 (0.78) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL5488342 0.87 CYP1A2 (0.77) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407689 0.85 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7408524 0.83 MAPK1 (0.62) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7410790 0.83 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7402313 0.81 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7409542 0.81 CYP1A2 (0.65) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002088096-A1 COMPOUNDS INHIBITING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES THEREOF NEURO3D (FR) 2002-11-07 WO disclosed